What Is Cryotherapy and What Materials Are Used for It? Nick Vasco | 3 minutes | January 31, 2025 Cryotherapy is a medical treatment that uses extremely cold temperatures to treat various conditions. It mainly relies on gases (that are in their liquid or solid state at low temperatures) like liquid nitrogen, carbon dioxide, and nitrous oxide. In this guide, we’ll cover the basic mechanism behind cryotherapy and discuss these fluids and solids in more detail. You’ll then learn a bit about the key safety protocols to follow during cryotherapy. Understanding Cryotherapy and Its Applications Cryotherapy has come a long way from the simple ice pack you might use for a sprained ankle – modern applications are much more sophisticated. Today’s cryotherapy treatments range from targeted local treatments to whole-body experiences. Cold temperatures are used precisely and purposefully to achieve specific results, from pain relief to decreased inflammation. Other common uses of cryotherapy include: Sports injuries Chronic pain management Destroying abnormal tissue The Science Behind Cryotherapy Materials When it comes to cryotherapy, not all fluids and solids are created equal – each option has unique properties and applications. Liquid nitrogen is the heavyweight champion of cryotherapy materials. It can reach temperatures as low as -196°C (-320.8°F), making it perfect for whole-body cryotherapy chambers and targeted treatments. Still, carbon dioxide (CO2) is often considered the safer alternative for many applications. While it doesn’t get quite as cold as liquid nitrogen – reaching only -79°C (-110.2°F) – it’s still cold enough for most therapeutic uses. Nitrous oxide (N2O) offers a middle ground, with a boiling point of -89°C (-128.2°F). However, it requires careful handling due to potential exposure risks in enclosed spaces. Applications and Safety Considerations The choice of material often depends on the specific application and safety requirements. For example, when performing cryosurgery in smaller, enclosed spaces, CO2 is often preferred over N2O because of the higher safety threshold for airborne exposure. Modern cryotherapy chambers typically use liquid nitrogen because it can maintain the extremely low temperatures needed for whole-body treatments. These sessions usually last between 2–5 minutes at temperatures ranging from -100°C to -140°C (-148°F to -220°F). Regardless of the material used, following the necessary safety protocols is paramount. Proper ventilation is essential (especially when using nitrous oxide), and all equipment must be regularly maintained and checked for leaks. Medical facilities and clinics offering cryotherapy services should pay special attention to their chosen gas supplier. The quality and purity of cryotherapy materials directly impact treatment effectiveness and safety, so make sure to partner with a reliable provider. The Future of Cryotherapy As technology advances, we’re seeing new applications for cryotherapy. From sports medicine to aesthetic treatments, the field continues to expand rapidly. Much of the current research is focused on optimizing material mixtures and delivery methods. Some facilities are exploring computer-controlled delivery systems that can provide more precise temperature control. The demand for both local and whole-body cryotherapy continues to grow. This growth drives innovation in both the technology and the materials used in these treatments. Get the Most Out of Cryotherapy With the Right Materials While cryotherapy might seem as simple as applying cold to an area, the science behind it is complex. The chosen material, delivery method, and safety protocols play crucial roles in treatment success. 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