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Analytical Chromatography

Get ultra high purity helium, hydrogen, nitrogen, and argon for analytical chromatography.

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Gases Used in Analytical Chromatography

Analytical Chromatography FAQs

Learn more about our analytical chromatography gases and the services we offer.

What is analytical chromatography?

Analytical chromatography is a laboratory technique that separates and identifies components in complex mixtures by passing a mobile phase (carrier gas) through a stationary phase. Compounds are separated based on their physical and chemical properties.

What role do industrial gases play in gas chromatography?

Industrial gases serve as the mobile phase (carrier gas) that transports the sample through the chromatography column and as support gases that enable detector functionality.

What are the benefits of using high-purity gases in chromatography?

High-purity gases minimize baseline noise, prevent false peaks, and protect expensive analytical columns from contamination damage. Ultra-high purity gases also ensure consistent, accurate results by preventing interference with detection systems.

How does helium compare to hydrogen as a carrier gas?

Helium is the most widely used carrier gas due to its inertness and safety. Hydrogen offers faster analysis times and higher efficiency according to Van Deemter curves, but requires strict safety protocols due to its flammability.

What technical considerations are important when selecting gases for analytical chromatography?

Gas purity grade must match analytical sensitivity requirements (ALPHAGAZ™ 1 for routine analysis; ALPHAGAZ™ 2 for trace detection). Column compatibility and detector type also dictate gas selection.

What safety precautions should be taken when using hydrogen?

When using hydrogen, implement leak detection systems, ensure proper ventilation, and consider on-site hydrogen generators to eliminate high-pressure storage risks. You should also use appropriate regulators with stainless-steel diaphragms to prevent contamination.

How are calibration gas mixtures used in analytical chromatography?

Calibration gas mixtures establish baseline responses and calibration curves for quantitative analysis. They’re also essential for method validation in quality control procedures.

What factors influence carrier gas selection for different applications?

Separation efficiency requirements, detector compatibility, safety considerations, budget constraints, and analysis speed all influence carrier gas selection. Helium works with virtually all detectors but faces supply issues, hydrogen offers fastest analysis but requires strict safety measures, and nitrogen is cost-effective but less efficient for many applications.

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