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Liquid Chromatography–Tandem Mass Spectrometry

Get ultra high purity nitrogen, helium, hydrogen, and argon for liquid chromatography-tandem mass spectrometry.

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Gases Used in Liquid Chromatography–Tandem Mass Spectrometry

Liquid Chromatography–Tandem Mass Spectrometry FAQs

Learn more about our liquid chromatography–tandem mass spectrometry gases and the services we offer.

What is liquid chromatography-tandem mass spectrometry (LC-MS/MS)?

LC-MS/MS is a technique that combines liquid chromatography separation with tandem mass spectrometry detection to identify and quantify compounds in complex samples.

How do industrial gases support LC-MS/MS operations?

Industrial gases serve as carrier gases, collision gases, and nebulizing gases that enable proper sample ionization, fragmentation, and detection. They must meet ultra high purity standards to prevent contamination and ensure accurate results.

What are the benefits of using high-purity gases in LC-MS/MS?

High-purity gases minimize background interference, improve signal-to-noise ratios, and extend instrument life. They also ensure consistent analytical performance and reduce maintenance requirements.

How is nitrogen used in LC-MS/MS systems?

Nitrogen is the main nebulizing gas in electrospray ionization sources that helps convert liquid samples into gas-phase ions for mass spectrometric analysis. It also functions as a drying gas to remove solvent molecules and as a curtain gas to prevent contamination of the ion source.

What role does helium play in LC-MS/MS applications?

Helium is used as a collision gas in triple quadrupole mass spectrometers, where it facilitates controlled fragmentation of precursor ions to generate characteristic product ions.

How is hydrogen used in LC-MS/MS operations?

Hydrogen serves as a collision gas alternative to helium and as a carrier gas in some LC-MS/MS configurations. It also works as a fuel gas for flame ionization detectors when LC-MS/MS systems are coupled with additional detection methods.

What purity levels are required for LC-MS/MS gases?

LC-MS/MS applications typically require ultra high purity gases (99.999% or higher) with extremely low moisture and hydrocarbon content. Specialized gas purification systems may be needed to achieve the stringent purity requirements.

Which industries commonly use LC-MS/MS with these gas requirements?

LC-MS/MS is widely used in pharmaceutical development, clinical diagnostics, environmental testing, food safety analysis, and forensic laboratories.

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